Article
Carboxylesterases in lipid metabolism: from mouse to human.
Protein & cell - 1 Feb 2018
Lian Jihong, Nelson Randal, Lehner Richard
Abstract excerpt
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent...
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