Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.

doi:10.1038/ng1131

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Article

Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.

Nature genetics - 1 Apr 2003

Winrow Christopher J, Hemming Matthew L, Allen Duane M, Quistad Gary B, Casida John E, Barlow Carrolee

Abstract excerpt

Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. We generated mice with disruptions in Nte, the gene encoding NTE. Nte(-/-) mice die after embryonic day 8, and Nte(+/-) mice have lower activity of Nte in the brain and higher mortality when exposed to the Nte-inhibiting compound...

Topics

Acetylcholinesterase
Alleles
Amino Acid Sequence
Animals
Blotting, Northern
Brain
Carboxylic Ester Hydrolases
Databases as Topic
Expressed Sequence Tags
Gene Expression Regulation
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hyperkinesis

In Situ Hybridization, Fluorescence

Insecticides

Mice

Mice, Transgenic

Models, Genetic

Source

Open in PubMed

Identifiers

PMID: 12640454
DOI: 10.1038/ng1131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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