Article
Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway.
Cellular microbiology - 1 Nov 1999
Moors M A, Auerbuch V, Portnoy D A
Abstract excerpt
Upon infection of mammalian cells, Listeria monocytogenes lyses the phagosome and enters the cytosol, where it secretes proteins necessary for its intracellular growth cycle. Consequently, bacterial proteins exposed to the cytosol are potential targets for degradation by host cytosolic proteases. One pathway for degradation of host cytosolic proteins, the N-end rule pathway, involves recognition of the N-terminal...
Topics
- Animals
- Arginine
- Bacterial Proteins
- Cell Line
- Colony Count, Microbial
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Half-Life
- Leupeptins
- Listeria monocytogenes
- Membrane Proteins
- Multienzyme Complexes
- Mutation
- Proteasome Endopeptidase Complex