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Article

Dispensable PDZ domain of Escherichia coli YaeL essential protease.

Molecular microbiology - 1 Apr 2004

Bohn Chantal, Collier Justine, Bouloc Philippe

Abstract excerpt

In Escherichia coli, adaptation to extra-cytoplasmic stress relies on sigma(E) activation to induce a rescue pathway. Under non-stressed conditions, sigma(E) is sequestered by the inner membrane protein RseA. Extra-cytoplasmic stress activates DegS-dependent cleavage of RseA, rendering RseA sensitive to further degradation by the YaeL protease. YaeL contains two motifs characteristic of a family of...

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Identifiers

PMID: 15066031
DOI: 10.1111/j.1365-2958.2004.03985.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dispensable PDZ domain of Escherichia coli YaeL essential protease.PMID 15066031Read ↗

YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA.Semantic proximity Read ↗

DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response.Semantic proximity Read ↗

PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σ(E) activation in vivo.Semantic proximity Read ↗

Characterization of the yaeL gene product and its S2P-protease motifs in Escherichia coli.Semantic proximity Read ↗

A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli.Semantic proximity Read ↗

YpdC determines site-1 degradation in regulated intramembrane proteolysis of the RsiW anti-sigma factor of Bacillus subtilis.Semantic proximity Read ↗

RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences.Semantic proximity Read ↗

A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP.Semantic proximity Read ↗

The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity.Semantic proximity Read ↗

Degradation of secreted proteins in Escherichia coli.Semantic proximity Read ↗

Function of site-2 proteases in bacteria and bacterial pathogens.Semantic proximity Read ↗

Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis.Semantic proximity Read ↗

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