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Article

The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.

The Journal of biological chemistry - 9 Nov 2012

Cassone Marco, Gagne Alyssa L, Spruce Lynn A, Seeholzer Steven H, Sebert Michael E

Abstract excerpt

The HtrA protease of Streptococcus pneumoniae functions both in a general stress response role and as an error sensor that specifically represses genetic competence when the overall level of biosynthetic errors in cellular proteins is low. However, the mechanism through which HtrA inhibits development of competence has been unknown. We found that HtrA digested the pneumococcal competence-stimulating peptide (CSP)...

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Identifiers

PMID: 23012372
DOI: 10.1074/jbc.M112.391482
PMCID: PMC3493890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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