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Article

Met-Lys-bradykinin-Ser-Ser, a peptide produced by the neutrophil from kininogen, is metabolically activated by angiotensin converting enzyme in vascular tissue.

Pharmacological research - 1 Nov 2011

Gera Lajos, Roy Caroline, Bawolak Marie-Thérèse, Bouthillier Johanne, Adam Albert, Marceau François

Abstract excerpt

Bradykinin (BK) is a vasoactive nonapeptide cleaved from circulating kininogens and that is degraded by angiotensin converting enzyme (ACE). It has been reported that the PR3 protease from human neutrophil releases an alternate peptide of 13 amino acids, Met-Lys-BK-Ser-Ser, from high molecular weight kininogen. We have studied vascular actions of this kinin. Its affinity for recombinant B₁ and B₂ receptors is...

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PMID: 21864683
DOI: 10.1016/j.phrs.2011.08.001

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ACE

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