Article
Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2001
van den Eijnden M M, Saris J J, de Bruin R J, de Wit E, Sluiter W, Reudelhuber T L, Schalekamp M A, Derkx F H, Danser A H
Abstract excerpt
ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to this production. Here, we investigated this possibility as well as prorenin a...
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