Article

Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B <sub>2</sub> receptor and peptidase resistance in rat

2016-12-17

Abstract excerpt

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B 2 receptor (B 2 R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance to inactivation by angiotensin converting enzyme (ACE), value as a module for the design of fusion proteins that bind to the B 2 R in mammalia...

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Literature Corpus work: caa6d729-66c2-53c0-bb9b-f8789cb59ce0
DOI: 10.7287/peerj.preprints.2641v1

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Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B <sub>2</sub> receptor and peptidase resistance in ratDOI 10.7287/peerj.preprints.2641v1Read

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