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Article

The influence of Lys68 in decepeptide agonists of C5a on C5a receptor binding, activation and selectivity.

The journal of peptide research : official journal of the American Peptide Society - 1 Jan 1999

Vogen S M, Finch A M, Wadi S K, Thatcher J, Monk P N, Taylor S M, Sanderson S D

Abstract excerpt

The potent, conformationally biased C5a agonist peptide YSFKPMPLaR (C5a65-74, Y65, F67, P69, P71, D-Ala73) was used as a template to gain insight into the nature and importance of lysine at position 68 in the peptide-receptor interaction. A panel of YSFKPMPLaR analogs with systematic substitutions for Lys68 was evaluated for C5a receptor (C5aR) binding affinity and activation in two well-characterized assay...

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Identifiers

PMID: 10195437
DOI: 10.1111/j.1399-3011.1999.tb01612.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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