Article
The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor.
Biological chemistry - 1 Apr 2016
Filippelli-Silva Rafael, Martin Renan P, Rodrigues Eliete S, Nakaie Clovis R, Oliveira Laerte, Pesquero João B, Shimuta Suma I
Abstract excerpt
Bradykinin (BK) is a nonapeptide important for several physiological processes such as vasodilatation, increase in vascular permeability and release of inflammatory mediators. BK performs its actions by coupling to and activating the B2 receptor, a family A G-protein coupled receptor. Using a strategy which allows systematical monitoring of BK R1 and R9 residues and B2 receptor acidic residues Glu5.35(226) and...
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