Article
Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection.
AIDS research and human retroviruses - 1 May 2012
Zuo Jun, Suen Jeffrey, Wong Alanna, Lewis Martha, Ayub Ali, Belzer Marvin, Church Joseph, Yang Otto O, Krogstad Paul
Abstract excerpt
Throughout the world, infants and children with HIV-1 infection are increasingly surviving into adolescence and adulthood. As HIV Nef is an important determinant of the pathogenic potential of the virus, we examined nef alleles in a cohort of extreme long-term survivors of HIV infection (average age of 16.6 years) to determine if Nef defects might have contributed to patient survival. HIV nef gene sequences were...
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