Evaluation of genetic diversity of human immunodeficiency virus type 1 NEF gene associated with vertical transmission.

doi:10.1007/BF02256435

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Article

Evaluation of genetic diversity of human immunodeficiency virus type 1 NEF gene associated with vertical transmission.

Journal of biomedical science - 1 Jan 2000

Hahn Tobias, Ramakrishnan Rajesh, Ahmad Nafees

Abstract excerpt

The NEF gene is conserved among members of human and simian immunodeficiency viruses and may play an important role in viral pathogenesis. To determine the evolutionary dynamics and conservation of functionality of the human immunodeficiency virus type 1 (HIV-1) NEF gene during maternal-fetal transmission, we analyzed NEF sequences from seven mother-infant pairs following perinatal transmission, including a...

Topics

Amino Acid Sequence
DNA, Viral
Epitopes, T-Lymphocyte
Female
Gene Products, nef
Genes, nef
Genetic Variation
HIV Infections
HIV-1
Humans
Infant
Infectious Disease Transmission, Vertical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Maternal-Fetal Exchange

Molecular Sequence Data

Phylogeny

Polymerase Chain Reaction

Pregnancy

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 12824703
DOI: 10.1007/BF02256435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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