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Article

CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.

Journal of virology - 1 Nov 2003

Casartelli Nicoletta, Di Matteo Gigliola, Potestà Marina, Rossi Paolo, Doria Margherita

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) nef gene is a crucial determinant in AIDS disease progression. Although several in vitro activities have been attributed to the Nef protein, identifying the one critical for in vivo pathogenicity remains elusive. In this study, we examined a large number of nef alleles derived at various time points from 13 perinatally infected children showing different progression...

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Source

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Identifiers

PMID: 14557639
DOI: 10.1128/jvi.77.21.11536-11545.2003
PMCID: PMC229262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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