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Article

Confocal fluorescence anisotropy and FRAP imaging of α-synuclein amyloid aggregates in living cells.

PloS one - 1 Jan 2011

Roberti M Julia, Jovin Thomas M, Jares-Erijman Elizabeth

Abstract excerpt

We assessed the intracellular association states of the Parkinson's disease related protein α-synuclein (AS) in living cells by transfection with a functional recombinant mutant protein (AS-C4) bearing a tetracysteine tag binding the fluorogenic biarsenical ligands FlAsH and ReAsH, The aggregation states of AS-C4 were assessed by in situ microscopy of molecular translational mobility with FRAP (fluorescence...

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Identifiers

PMID: 21858077
DOI: 10.1371/journal.pone.0023338
PMCID: PMC3152574

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