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Article

Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.

The American journal of pathology - 1 Oct 2011

Van Hul Noémi, Lanthier Nicolas, Español Suñer Regina, Abarca Quinones Jorge, van Rooijen Nico, Leclercq Isabelle

Abstract excerpt

Activation of myofibroblasts (MF) and extracellular matrix (ECM) deposition predispose the expansion and differentiation of liver progenitor cells (LPC) during chronic liver injury. Because Kupffer cells (KC) are active modulators of tissue response and fibrosis, we analyzed their role in a model of LPC proliferation. A choline-deficient diet, supplemented by ethionine (CDE) was administrated to C57Bl/6J mice...

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Identifiers

PMID: 21854752
DOI: 10.1016/j.ajpath.2011.06.042
PMCID: PMC3181378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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