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Repopulating Kupffer cells originate directly from hematopoietic stem cells

10 Dec 2023

Abstract excerpt

BACKGROUND: Kupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input of circulating monocytes (MOs) at a steady state and are replenished within 2 weeks after having been depleted, but the origin of repopulating KCs in adults remains unclear. The current paradigm dictates that repopulating KCs originate from preexisting KCs or...

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PMID: 38072929
DOI: 10.1186/s13287-023-03569-0

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