Article
Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver.
Gut - 1 May 2010
Lorenzini Stefania, Bird Thomas G, Boulter Luke, Bellamy Christopher, Samuel Kay, Aucott Rebecca, Clayton Elizabeth, Andreone Pietro, Bernardi Mauro, Golding Mathew, Alison Malcolm R, Iredale John P, Forbes Stuart J
Abstract excerpt
BACKGROUND: Stem/progenitor cell niches in tissues regulate stem/progenitor cell differentiation and proliferation through local signalling. OBJECTIVE: To examine the composition and formation of stem progenitor cell niches. METHODS: The composition of the hepatic progenitor cell niche in independent models of liver injury and hepatic progenitor cell activation in rodents and humans was studied. To identify the...
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