Article
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross.
Nature - 17 May 1990
Wellems T E, Panton L J, Gluzman I Y, do Rosario V E, Gwadz R W, Walker-Jonah A, Krogstad D J
Abstract excerpt
Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites resistant to chloroquine expel the drug rapidly in an unaltered form, thereby reducing levels of accumulation in the vesicles. The discovery...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Base Sequence
- Chloroquine
- Crosses, Genetic
- Drug Resistance
- Gene Amplification
- Genes
- Membrane Glycoproteins
- Molecular Sequence Data
- Oligonucleotide Probes