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Article

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross.

Nature - 17 May 1990

Wellems T E, Panton L J, Gluzman I Y, do Rosario V E, Gwadz R W, Walker-Jonah A, Krogstad D J

Abstract excerpt

Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites resistant to chloroquine expel the drug rapidly in an unaltered form, thereby reducing levels of accumulation in the vesicles. The discovery that verapamil partially reverses chloroquine resistance in vitro led to the proposal that efflux may involve an...

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PMID: 1970614
DOI: 10.1038/345253a0

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