Article
Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region.
Antimicrobial agents and chemotherapy - 1 Aug 2009
Orjuela-Sánchez Pamela, de Santana Filho Franklin Simões, Machado-Lima Ariane, Chehuan Yonne Francis, Costa Mônica Regina Farias, Alecrim Maria das Graças Costa, del Portillo Hernando A
Abstract excerpt
Plasmodium vivax parasites with chloroquine resistance (CQR) are already circulating in the Brazilian Amazon. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of the pvmdr1 and pvcrt-o genes revealed no associations with CQR, even if some mutations had not been randomly selected. In addition, striking differences in the topologies and numbers of SNPs in these transporter...
Topics
- Animals
- Antimalarials
- Brazil
- Chloroquine
- Drug Resistance
- Membrane Transport Proteins
- Models, Biological
- Molecular Sequence Data
- Multidrug Resistance-Associated Proteins
- Plasmodium vivax
- Polymorphism, Single Nucleotide
- Protozoan Proteins