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Article

RNA interference machinery influences the nuclear organization of a chromatin insulator.

Nature genetics - 1 Aug 2006

Lei Elissa P, Corces Victor G

Abstract excerpt

RNA interference (RNAi) is a conserved silencing mechanism that can act through alteration of chromatin structure. Chromatin insulators promote higher-order nuclear organization, thereby establishing DNA domains subject to distinct transcriptional controls. We present evidence for a functional relationship between RNAi and the gypsy insulator of D. melanogaster. Insulator activity is decreased when Argonaute...

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PMID: 16862159
DOI: 10.1038/ng1850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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