Inhibition of transcription of cytosine-containing DNA in vitro by the alc gene product of bacteriophage T4.

doi:10.1128/jb.172.5.2716-2727.1990

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Article

Inhibition of transcription of cytosine-containing DNA in vitro by the alc gene product of bacteriophage T4.

Journal of bacteriology - 1 May 1990

Drivdahl R H, Kutter E M

Abstract excerpt

The alc gene product (gpalc) of bacteriophage T4 inhibits the transcription of cytosine-containing DNA in vivo. We examined its effect on transcription in vitro by comparing RNA polymerase isolated from Escherichia coli infected with either wild-type T4D+ or alc mutants. A 50 to 60% decline in RN...

Topics

Chloramphenicol
Cytosine
DNA, Viral
DNA-Directed RNA Polymerases
Escherichia coli
Kinetics
Mutation
T-Phages
Templates, Genetic
Transcription, Genetic
Viral Proteins

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