Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations.

doi:10.1128/JB.183.7.2289-2297.2001

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Article

Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations.

Journal of bacteriology - 1 Apr 2001

Cicero M P, Sharp M M, Gross C A, Kreuzer K N

Abstract excerpt

Bacteriophage T4 middle-mode transcription requires two phage-encoded proteins, the MotA transcription factor and AsiA coactivator, along with Escherichia coli RNA polymerase holoenzyme containing the sigma(70) subunit. A motA positive control (pc) mutant, motA-pc1, was used to select for suppressor mutations that alter other proteins in the transcription complex. Separate genetic selections isolated two AsiA...

Topics

Bacteriophage T4
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Escherichia coli
Mutation
Promoter Regions, Genetic
Sigma Factor
Transcription Factors
Transcription, Genetic
Viral Proteins

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Identifiers

PMID: 11244069
DOI: 10.1128/JB.183.7.2289-2297.2001
PMCID: PMC95136

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