Article
Regulatory elements for expression of the alkA gene in response to alkylating agents.
Molecular & general genetics : MGG - 1 Dec 1992
Furuichi M, Yu C G, Anai M, Sakumi K, Sekiguchi M
Abstract excerpt
Expression of the alkA gene in Escherichia coli is controlled by Ada protein, which binds to a specific region of the alkA promoter and enhances further binding of RNA polymerase holoenzyme to the complex. To determine the sequence recognized by the Ada protein, we introduced various base substit...
Topics
- Alkylating Agents
- Bacterial Proteins
- Base Sequence
- DNA Glycosylases
- DNA, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Methylation
- Molecular Sequence Data
- Mutation
- N-Glycosyl Hydrolases
- O(6)-Methylguanine-DNA Methyltransferase
- Plasmids
- Promoter Regions, Genetic
- Transcription Factors
- Transcription, Genetic