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Article

Regulation of pyrG expression in Bacillus subtilis: CTP-regulated antitermination and reiterative transcription with pyrG templates in vitro.

Molecular microbiology - 1 Mar 2007

Jensen-MacAllister Irene E, Meng Qi, Switzer Robert L

Abstract excerpt

The regulation of pyrG expression in a group of low GC Gram-positive bacteria was previously shown to be mediated by a novel form of transcription attenuation in which low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the pyrG mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base...

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Identifiers

PMID: 17302819
DOI: 10.1111/j.1365-2958.2007.05595.x

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