Article
Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 1999
Sonntag W E, Lynch C D, Cefalu W T, Ingram R L, Bennett S A, Thornton P L, Khan A S
Abstract excerpt
Moderate caloric restriction (60% of ad libitum intake) is an important model to investigate potential mechanisms of biological aging. This regimen has been reported to decrease the number of pathologies and increase life span in all species tested to date. Although moderate caloric restriction induces a wide range of physiological changes within the organism, adaptive changes within the endocrine system are...
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