Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Consequences of growth hormone (GH) overexpression and GH resistance.

Neuropeptides - 1 Jan 2000

Bartke A, Chandrashekar V, Bailey B, Zaczek D, Turyn D

Abstract excerpt

Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals revealed previously unsuspected actions of GH and IGF-I on neuroendocrine functions related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fertility
Share to Growth Hormone
Share to Insulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Longevity

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Receptors, Somatotropin

Source

Identifiers

PMID: 12359510
DOI: 10.1054/npep.2002.0889

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Consequences of growth hormone (GH) overexpression and GH resistance.PMID 12359510Read ↗

Neuroendocrine and Reproductive Consequences of Overexpression of Growth Hormone in Transgenic MiceSemantic proximity Read ↗

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.Semantic proximity Read ↗

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and LongevitySemantic proximity Read ↗

Pleiotropic effects of growth hormone signaling in aging.Semantic proximity Read ↗

Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice.Semantic proximity Read ↗

GH and ageing: Pitfalls and new insights.Semantic proximity Read ↗

Genes that prolong life: relationships of growth hormone and growth to aging and life span.Semantic proximity Read ↗

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.Semantic proximity Read ↗

Impact of Growth Hormone-Related Mutations on Mammalian AgingSemantic proximity Read ↗

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in FemalesSemantic proximity Read ↗

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.Semantic proximity Read ↗

The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of GrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.