Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner

28 Aug 2020

Abstract excerpt

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was recently found to elicit health benefits, including improved insulin sensitivity and extend longevity exclusively in male mice. Given that 17β-E2 is known to modulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Growth Hormone and Insulin-like Growth Factors
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32857104
DOI: 10.1093/gerona/glaa215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific MannerPMID 32857104Read ↗

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor αSemantic proximity Read ↗

Pleiotropic effects of growth hormone signaling in aging.Semantic proximity Read ↗

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and LongevitySemantic proximity Read ↗

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female miceSemantic proximity Read ↗

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity Read ↗

Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responsesSemantic proximity Read ↗

Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin StatesSemantic proximity Read ↗

The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice.Semantic proximity Read ↗

Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.Semantic proximity Read ↗

Healthspan and longevity can be extended by suppression of growth hormone signalingSemantic proximity Read ↗

Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.Semantic proximity Read ↗

Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1aSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.