Article
Genome scans for transmission ratio distortion regions in mice.
Genetics - 1 May 2012
Casellas Joaquim, Gularte Rodrigo J, Farber Charles R, Varona Luis, Mehrabian Margarete, Schadt Eric E, Lusis Aldon J, Attie Alan D, Yandell Brian S, Medrano Juan F
Abstract excerpt
Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and embryonic development, and early neonatal life. Although a few TRD loci have been reported in mouse, inheritance patterns have never been evaluated for TRD. In this article, we...
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