Article
miR-101 DNA copy loss is a prominent subtype specific event in lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2011
Thu Kelsie L, Chari Raj, Lockwood William W, Lam Stephen, Lam Wan L
Abstract excerpt
INTRODUCTION: MicroRNA-101 (miR-101) is frequently downregulated in cancer and exhibits antitumorigenic properties, suggesting that miR-101 is a putative tumor suppressor. miR-101 is encoded at two loci in the human genome: 1p31.3 (miR-101-1) and 9p24.1 (miR-101-2). We sought to investigate miR-101 locus-specific deletions and genomic loss in the major subtypes of lung cancer. METHODS: Analyses of high-resolution...
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