Smoking-related Genomic Signatures in Non–Small Cell Lung Cancer

Abstract excerpt

RATIONALE: Tobacco smoking is responsible for 85% of all lung cancers. To further our understanding of the molecular pathogenesis of lung cancer, we determined whether smoking history leads to the emergence of specific genomic alterations found in non-small cell lung cancer (NSCLC). OBJECTIVES: To identify gene copy number alterations in NSCLCs associated with smoking history or DNA repair capacity. METHODS:...

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