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Article

Frequent Loss of CACNA1C Is Associated With Poor Prognosis in Non-Small Cell Lung Cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 28 Feb 2026

Dasgupta Saanvi, Galappaththi Sapthala L, Banerjee Rajarshi, Alsatari Enas S, Pramanik Paramahansa, Marbut Stephen M, Yunus Furhan, Galeas Jose N, Dasgupta Santanu

Abstract excerpt

Lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are common histologic subtypes of non-small cell lung cancer (NSCLC), usually diagnosed at advanced stages with a dismal survival rate. A high-resolution SNP array (Affymetrix 250 NspI) analysis of five primary NSCLC tumors and their follow-up mucosal biopsies (n = 25) identified frequent copy neutral loss of heterozygosity (LOH, loss of 59 SNPs) of...

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Share to Calcium Channels, L-Type
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Loss of Heterozygosity

Share to Lung Neoplasms

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Source

Identifiers

PMID: 41729014
DOI: 10.1096/fj.202504868R

Genes

CACNA1C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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