Article
Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2011
Alves Markênia Kélia Santos, Ferrasi Adriana Camargo, Lima Valeska Portela, Ferreira Márcia Valéria Pitombeira, de Moura Campos Pardini Maria Inês, Rabenhorst Silvia Helena Barem
Abstract excerpt
OBJECTIVE: We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. METHODS: DNA extracted from 76 H. pylori-positive gastric tumor samples was available for promoter methylation identification by methylation-specific PCR and H. pylori subtyping by PCR. Immunohistochemistry was used...
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