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Article

CpG Island Hypermethylation of Tumor‐Suppressor Genes in H. pylori‐Infected Non‐Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk

14 Jan 2008

Abstract excerpt

BACKGROUND AND AIM: Gastric carcinogenesis involves CpG island hypermethylation (CIHM) of tumor-suppressor genes. Although the CIHM of these genes occurs in non-neoplastic gastric cells, it is unclear whether this epigenetic alteration is linked with aging and/or gastric cancer risk. We investigated this linkage in noncancerous gastric mucosa infected with H. pylori. SUBJECTS AND METHODS: Noncancerous corpus...

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PMID: 18205664
DOI: 10.1111/j.1523-5378.2008.00572.x

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