Article
Methylation status of CDH1 gene in samples of gastric mucous from Brazilian patients with chronic gastritis infected by Helicobacter pylori.
Arquivos de gastroenterologia - 1 Jan 2000
Kague Erika, Thomazini Cristiane Melissa, Pardini Maria Inês de Campo Moura, Carvalho Fabrício de, Leite Celso Vieira, Pinheiro Nídia Alice
Abstract excerpt
CONTEXT: Gastric cancer is one of the top list of cancer types that most leads to death in Brazil and worldwide. Helicobacter pylori(H. pylori) is a class I carcinogen and infect almost 90% of chronic gastritis patients. Some genotypes confer different virulent potential to H. pylori and can increase the risk of gastritis development. Methylation of CpG islands can inactivate tumor suppressor genes and therefore,...
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