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Article

Including additional controls from public databases improves the power of a genome-wide association study.

Human heredity - 1 Jan 2011

Mukherjee Semanti, Simon Jennifer, Bayuga Sharon, Ludwig Emmy, Yoo Sarah, Orlow Irene, Viale Agnes, Offit Kenneth, Kurtz Robert C, Olson Sara H, Klein Robert J

Abstract excerpt

Though genome-wide association studies (GWAS) have identified numerous susceptibility loci for common diseases, their use is limited due to the expense of genotyping large cohorts of individuals. One potential solution is to use 'additional controls', or genotype data from control individuals deposited in public repositories. While this approach has been used by several groups, the genetically heterogeneous...

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Identifiers

PMID: 21849791
DOI: 10.1159/000330149
PMCID: PMC3171281

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