Article

Expanding the pool of public controls for GWAS via a method for combining genotypes from arrays and sequencing

2021-10-20

Abstract excerpt

Genome-wide association studies (GWAS) have made impactful discoveries for complex diseases, often by amassing very large sample sizes. Yet, GWAS of many diseases remain underpowered, especially for non-European ancestries. One cost-effective approach to increase sample size is to combine existing case-only cohorts with public controls, but this approach is limited by the need for a large overlap in variants acros...

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Literature Corpus work: 9bff870b-6da3-55b6-b336-7f16e43ef976
DOI: 10.1101/2021.10.19.464854

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