Article
The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data.
PLoS genetics - 2 Sept 2010
Chen Gary K, Millikan Robert C, John Esther M, Ambrosone Christine B, Bernstein Leslie, Zheng Wei, Hu Jennifer J, Chanock Stephen J, Ziegler Regina G, Bandera Elisa V, Henderson Brian E, Haiman Christopher A, Stram Daniel O
Abstract excerpt
We consider the feasibility of reusing existing control data obtained in genetic association studies in order to reduce costs for new studies. We discuss controlling for the population differences between cases and controls that are implicit in studies utilizing external control data. We give theoretical calculations of the statistical power of a test due to Bourgain et al (Am J Human Genet 2003), applied to the...
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