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Article

Improving power for rare-variant tests by integrating external controls.

Genetic epidemiology - 1 Nov 2017

Lee Seunggeun, Kim Sehee, Fuchsberger Christian

Abstract excerpt

Due to the drop in sequencing cost, the number of sequenced genomes is increasing rapidly. To improve power of rare-variant tests, these sequenced samples could be used as external control samples in addition to control samples from the study itself. However, when using external controls, possible batch effects due to the use of different sequencing platforms or genotype calling pipelines can dramatically...

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PMID: 28657150
DOI: 10.1002/gepi.22057
PMCID: PMC6082405

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