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Article

Population substructure and control selection in genome-wide association studies.

PloS one - 2 Jul 2008

Yu Kai, Wang Zhaoming, Li Qizhai, Wacholder Sholom, Hunter David J, Hoover Robert N, Chanock Stephen, Thomas Gilles

Abstract excerpt

Determination of the relevance of both demanding classical epidemiologic criteria for control selection and robust handling of population stratification (PS) represents a major challenge in the design and analysis of genome-wide association studies (GWAS). Empirical data from two GWAS in European Americans of the Cancer Genetic Markers of Susceptibility (CGEMS) project were used to evaluate the impact of PS in...

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Identifiers

PMID: 18596976
DOI: 10.1371/journal.pone.0002551
PMCID: PMC2432498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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