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Article

A new approach to account for the correlations among single nucleotide polymorphisms in genome: wide association studies.

Human heredity - 1 Jan 2011

Chen Zhongxue, Liu Qingzhong

Abstract excerpt

In genetic association studies, such as genome-wide association studies (GWAS), the number of single nucleotide polymorphisms (SNPs) can be as large as hundreds of thousands. Due to linkage disequilibrium, many SNPs are highly correlated; assuming they are independent is not valid. The commonly used multiple comparison methods, such as Bonferroni correction, are not appropriate and are too conservative when...

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Identifiers

PMID: 21849789
DOI: 10.1159/000330135
PMCID: PMC3171280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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