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Article

Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation.

Cardiovascular research - 1 Nov 2011

Wei Hsi-Ju, Li Yi-Heng, Shi Guey-Yueh, Liu Shu-Lin, Chang Po-Chiao, Kuo Cheng-Hsiang, Wu Hua-Lin

Abstract excerpt

AIMS: Thrombin modulates the formation of atherosclerotic lesions by stimulating a variety of cellular effects through protease-activated receptor-1 (PAR-1) activation. Thrombomodulin (TM) inhibits thrombin effects by binding thrombin through its domains 2 and 3 (TMD23). We investigated whether recombinant TMD23 (rTMD23) could inhibit atherosclerosis via its thrombin-binding ability. METHODS AND RESULTS:...

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Source

Identifiers

PMID: 21840881
DOI: 10.1093/cvr/cvr220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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