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Tryptophan 387 and 390 residues in ADAMTS13 are crucial to the ability of vascular tube formation and cell migration of endothelial cells.

Clinical and experimental pharmacology & physiology - 1 Aug 2020

Liu Ling, Ma Zhenni, Zhou Xuemei, Yin Jie, Lu Jun, Su Jian, Shen Fei, Xie Liqian, Hu Shaoyan, Ling Jing

Abstract excerpt

A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) was mainly generated and secreted from endothelial cells (ECs). Our previous study showed that tryptophan (Trp) residues at 387 and 390 in ADAMTS13 are required for its secretion and enzymatic activity. However, the effects on its host cell as well as the potential mechanism have not been clear. The aim of the study was to examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32222985
DOI: 10.1111/1440-1681.13313

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