Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.

Biochemical and biophysical research communications - 13 May 2016

Kawamoto Eiji, Okamoto Takayuki, Takagi Yoshimi, Honda Goichi, Suzuki Koji, Imai Hiroshi, Shimaoka Motomu

Abstract excerpt

LFA-1 (αLβ2) and Mac-1 (αMβ2) integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells. Here we have shown that the anti-coagulant molecule thrombomodulin (TM), found on the surface of endothelial cells, functions as a potentially new ligand for leukocyte integrins. We generated a recombinant extracellular domain of human TM and Fc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD18 Antigens
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Lymphocyte Function-Associated Antigen-1

Share to Macrophage-1 Antigen

Share to Protein Binding

Share to Protein Interaction Domains and Motifs

Share to Thrombomodulin

Source

Identifiers

PMID: 27055590
DOI: 10.1016/j.bbrc.2016.04.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.PMID 27055590Read ↗

Biology and structure of leukocyte β2 integrins and their role in inflammationSemantic proximity Read ↗

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer ProgressionSemantic proximity Read ↗

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).Semantic proximity Read ↗

An immunologist's guide to CD31 function in T-cellsSemantic proximity Read ↗

The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain.Semantic proximity Read ↗

Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma.Semantic proximity Read ↗

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial CellSemantic proximity Read ↗

Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation.Semantic proximity Read ↗

The same endothelial receptor controls lymphocyte traffic both in vascular and lymphatic vesselsSemantic proximity Read ↗

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitroSemantic proximity Read ↗

LW protein: a promiscuous integrin receptor activated by adrenergic signaling.Semantic proximity Read ↗

Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.