[Analysis of the effect of replacing Lys(-20) in the alkaline phosphatase signal peptide on secretion of this enzyme].

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Article

[Analysis of the effect of replacing Lys(-20) in the alkaline phosphatase signal peptide on secretion of this enzyme].

Biokhimiia (Moscow, Russia) - 1 Apr 1996

Karamysheva Z N, Karamyshev A L, Ksenzenko V N, Nesmeianova M A

Abstract excerpt

The effect of substitutions for the positively charged Lys(-20) in the N-terminal domain of the E. coli alkaline phosphatase signal peptide on enzyme secretion has been studied. Mutant alkaline phosphatases were obtained by the amber-suppressor method. An amber mutation was introduced in the appr...

Topics

Alkaline Phosphatase
Amino Acid Sequence
Base Sequence
Biological Transport
Cell Membrane
Cytoplasm
Escherichia coli
Lysine
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Protein Sorting Signals

Source

Open in PubMed

Identifiers

PMID: 8724791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8724791-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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