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Article

Association Between Elevated Depressive Symptoms and Cognitive Function Moderated by APOE4 Status: Framingham Offspring Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Piers Ryan J, Liu Yulin, Ang Ting F A, Tao Qiushan, Au Rhoda, Qiu Wei Qiao

Abstract excerpt

BACKGROUND: Depression and Apolipoprotein E4 (APOE4) are associated with decreased cognitive function and differences in brain structure. OBJECTIVE: This study investigated whether APOE4 status moderates the association between elevated depressive symptoms, cognitive function, and brain structure. METHODS: Stroke- and dementia-free participants (n = 1,968) underwent neuropsychological evaluation, brain MRI, and...

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Identifiers

PMID: 33646152
DOI: 10.3233/JAD-200998
PMCID: PMC8172078

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