Article
The joint effect of apolipoprotein E epsilon4 and MRI findings on lower-extremity function and decline in cognitive function.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2000
Carmelli D, DeCarli C, Swan G E, Kelly-Hayes M, Wolf P A, Reed T, Guralnik J M
Abstract excerpt
BACKGROUND: Cognitive decline and poor physical function are risk factors for disability in old age and may occur more often in subjects with the apolipoprotein E epsilon4 (ApoE-epsilon4) allele. The objective of this study was to investigate the joint effect of ApoE-epsilon4 and structural changes detected on MRI brain scans on cognitive decline and lower-extremity function. METHODS: Brain MRI (1.5 T),...
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