Article
Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 May 1990
Dancis A, Klausner R D, Hinnebusch A G, Barriocanal J G
Abstract excerpt
The requirement for a reduction step in cellular iron uptake has been postulated, and the existence of plasma membrane ferric reductase activity has been described in both procaryotic and eucaryotic cells. In the yeast Saccharomyces cerevisiae, there is an externally directed reductase activity that is regulated by the concentration of iron in the growth medium; maximal activity is induced by iron starvation. We...
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