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Article

Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae.

Journal of general microbiology - 1 Feb 1992

Eide D, Guarente L

Abstract excerpt

We have selected for genes that, when present in multiple copies, enhance growth of wild-type cells of Saccharomyces cerevisiae in an iron-limiting medium. A gene designated FUP1, for 'ferric utilization proficient', was isolated by this approach. Increased dosage of FUP1 reduces the concentration of iron in the medium required for efficient growth and confers elevated levels of iron uptake activity in...

Topics

Amino Acid Sequence
Chromosome Deletion
DNA-Binding Proteins
Edetic Acid
Fungal Proteins
Immediate-Early Proteins
Iron
Molecular Sequence Data
Mutation
Oxidation-Reduction
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Transcription Factors

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Identifiers

PMID: 1564445
DOI: 10.1099/00221287-138-2-347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1564445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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