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Article

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

1 Jul 2010

Abstract excerpt

Heterogeneous ribonucleoproteins (hnRNPs) are multifunctional RNA-binding proteins (RBPs) involved in many cellular processes. They participate in most gene expression pathways, from DNA replication and repair to mRNA translation. Among this class of proteins, TDP-43 (and more recently FUS/TLS) have received considerable attention due to their involvement in several neurodegenerative diseases. This finding has...

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PMID: 20639693
DOI: 10.4161/rna.7.4.12205

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