Accumulation of pre-tRNA splicing '2/3' intermediates in a Saccharomyces cerevisiae mutant.

doi:10.1002/j.1460-2075.1990.tb08232.x

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Article

Accumulation of pre-tRNA splicing '2/3' intermediates in a Saccharomyces cerevisiae mutant.

The EMBO journal - 1 Apr 1990

Ho C K, Rauhut R, Vijayraghavan U, Abelson J

Abstract excerpt

In an effort to identify genes involved in the excision of tRNA introns in Saccharomyces cerevisiae, temperature-sensitive mutants were screened for intracellular accumulation of intron-containing tRNA precursors by RNA hybridization analysis. In one mutant, tRNA splicing intermediates consisting...

Topics

Base Sequence
Blotting, Northern
Endoribonucleases
Genes, Fungal
Introns
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Phenotype
Plasmids
RNA Precursors
RNA Splicing
RNA, Transfer
Saccharomyces cerevisiae
Temperature

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